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¡¡¡¡ÈÃÎÒÃǻص½1919Ä꣬ÃÀ¹úµÄÉúÎﻯѧ¼ÒÂÞ½Ü J ÍþÁ®Ä·Ë¹£¨Roger J. Williams£©»¹ÔÚËûµÄʵÑéÊÒÀïÍæÈý½ÇÆ¿¡£Ëû¸Õ¸Õ×¢Òâµ½¶¯Ö²ÎïÖй㷺´æÔÚ×ÅÒ»¸öС·Ö×Ó [1] ¡£µ«ÊÇ£¬Ëû¼ÈδÄÜ·ÖÀëÌá´¿Õâ¸ö·Ö×Ó£¬Ò²²»ÍêÈ«Á˽âËüµÄ×÷Óã¬ÉõÖÁÉÐδ¸øËüÈ¡¹ýÏñÑùµÄÃû×Ö¡£ÍþÁ®Ä·Ë¹µÄµÚһƪÎÄÏ×Ò»·¢±í£¬Ðí¶àÑо¿×é¸ú·ç¶øÉÏ£¬·×·×ͶÈëÏà¹ØÑо¿ [2] ¡£14Äêºó£¬ÍþÁ®Ä·Ë¹ÖÕÓÚ´Ó¶¯Îï¸ÎÔàÖзÖÀë³öÁËÕâ¸ö·Ö×Ó£¬²¢¸øÁËËüÒ»¸öÃû×Ö¡ª¡ª¡°Pantothenic Acid¡±£¬Ô´×ÔÏ£À°ÓÒâΪ¡°Ëæ´¦¿É¼ûµÄËᡱ£¬¼´¡°·ºËᡱ [3] £¬Ò²¾ÍÊǺóÀ´ÈËÃÇËùÊìÖªµÄ¡°Î¬ÉúËØB5¡±¡££¨¶ø¡°·º´¼¡±£¬¾ÍÊÇ·ºËáµÄǰÌ壬ÓÖ³ÆÎ¬ÉúËØÔ­B5£©

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¡¡¡¡²»¾Ã£¬D W ÎéÀû£¨D. W. Woolley£©±¨µÀÁË·ºËáÓëС°×Êó¿¹ÍÑëÏà¹ØµÄÑо¿³É¹û [5] ¡£¹¤Òµ½çÖÕÓڵȵ½ÁËÊôÓÚËûÃǵĻú»á£¬»¤·ô¡¢»¤·¢µÈ¸öÈË»¤ÀíÏà¹ØÐÐÒµ¿ªÊ¼Ñ¸ËÙÑз¢Ð²úÆ·£¬ÔÚÆäÖÐÌí¼Ó·ºËá¡£¡°ÅËæÃ¡±¾ÍÊÇÔÚÕâÑùµÄ±³¾°Ïµ®ÉúµÄ¡£Ôڴ˺óµÄ¼¸Ê®ÄêÀºäºäÁÒÁÒµØÕ¹¿ªÁËËü×÷Ϊһ¸ö¡°Ð¡·Ö×Ó¡±µÄÆ·ÅÆ´«Ææ¹ÊÊ¡£

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¡¡¡¡[1] Williams, R. J., ¡°The Vitamine Requirement of Yeasts, A Simple Biological Test for Vitamine,¡± J. Biol. Chem., 38, 465 (1919)

¡¡¡¡[2] A. T. RINGROSE, L. C. NORRIS and G. P. HEUSER, ¡°The Occurrence of a Pellagra-Like Syndrome in Chicks¡± Poult Sci., 10:166-177. doi:10.3382/ps.0100166 (1931)

¡¡¡¡[3] Williams, R. J., Lyman, C. M., Goodyear, G. H., Truesdail, J. H. and Holaday, D., ¡°Pantothenic Acid, A Growth Determinant of Universal Biological Occurrence,¡± J. Am. Chem. Soc., 55, 2912-27 (1933)

¡¡¡¡[4] Eric T. Stiller, Stanton A. Harris, Jacob Finkelstein, John C. Keresztesy, Karl Folkers, ¡°Pantothenic Acid. VIII. The Total Synthesis of Pure Pantothenic Acid¡± J. Am. Chem. Soc., 62 (7), pp 1785¨C1790 (1940)

¡¡¡¡[5] Woolley, D. W., Identification of the mouse antialopecia factor. J. Biol. Chem. 139(1): 29-34. (1941)

¡¡¡¡[6] Just The Facts-Inventions & Discoveries, School Specialty Publishing, 2005

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